Ventoxen 100 mg Tablet (Venetoclax)

Ventoxen 100 mg is an oral BCL-2 inhibitor used to treat adults with chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL). First approved under the brand name Venclexta, this medicine works by blocking BCL-2 and helping cancer cells undergo programmed cell death.

On the other hand, Ventoxen 100 mg is a generic version of Venclexta, manufactured and marketed for export by Everest Pharmaceuticals Ltd., Bangladesh. 

What is Venetoclax 100 mg tablet used for (Indications)?

This oral medication is used for the treatment of adult patients who have been diagnosed with an FDA-approved test

• Chronic Lymphocytic Leukemia (CLL) and Small Lymphocytic Lymphoma (SLL).
• Acute Myeloid Leukemia (AML) in combination with Azacitidine and r decitabine or low-dose cytarabine for the treatment of adult patients who are 75 years old or more, or who have comorbidities that preclude use of intensive induction chemotherapy.
• There is no evidence of the safety and efficacy in children. 

 How does Ventoxen 100 mg work in Leukemia?

Ventoxen is a selective and orally bioavailable small-molecule inhibitor of the BCL-2 protein. This prevents cancer cells from dying, allowing them to survive longer than they should and making them resistant to some treatments. The medication attaches to the BCL-2 protein and blocks its action, which frees up the body’s natural “cell death signals.” This allows the cancer cells to break down their protective barrier, release signals inside the cell, and activate enzymes (called caspases) that trigger the cancer cells to die. In simple terms, this drug helps the body restart the natural process of removing cancer cells that were previously protected from dying.

How is Ventoxen administered, and what are the doses?

Recommended dose for the treatment of chronic lymphocytic leukemia/small lymphocytic lymphoma

To treat CLL/SLL, dosing starts with a 5-week ramp-up schedule, which is designed to gradually reduce tumor burden and decrease the risk of Tumor Lysis Syndrome.

• The week one daily dose is 20 mg
• Week two daily dose is 50 mg
• Week three daily dose is 100 mg
• Week 4 daily dose is 200 mg 
• Week 5 daily dose is 400 mg 
• After 5 weeks, the recommended dose is 400 mg once daily after completing the 5-week ramp-up schedule.
• It should be taken orally once daily until disease progression and unacceptable toxicity are observed.

To treat acute myeloid leukemia, the dose depends on the combination of agents. The dosing schedule for the ramp-up phase in patients with AML is

• Day-1: 100 mg
• Day-2: 200 mg
• Day-3: 300 mg 
• Day-4 and beyond: 400 mg when dosing in combination with azacitidine or decitabine and 600 mg when dosing in combination with low-dose cytarabine.

Administration should be as follows

• Take the medication after eating food with water. Do not chew or crush the tablet; swallow it whole with a full glass of water. 
• Perform prophylaxis for tumor lysis syndrome.

What are the possible side effects of the Venetoclax tablet?

Ventoxen can cause serious side effects, including:

• Low white blood cell count (Neutropenia). Low white blood cells are common in Ventoxen, but can be severe. Your doctor will perform blood tests during the treatment to check the blood cell count.
• Infections. Pneumonia and blood infections have occurred during the treatment. Close monitoring is important in case of a high fever to detect infections. 

The most common side effects of Ventoclex when used in combination with obinutuzumab or rituximab or alone in people with CLL or SLL include:

• low platelet counts
• low red blood cell counts
• Diarrhea
• nausea 
• upper respiratory tract infection
• Cough
• muscle and joint pain
• Tiredness
• Swelling of your arms, legs, hands, and feet

The most common side effects of Ventoxen in combination with azacitidine or decitabine, or low-dose cytarabine in people with AML include:  

• Nausea
• Diarrhea
• Low platelet count
• Constipation
• Fever with low white blood cell count
• Low red blood cell count
• Infection in the blood 
• Rash 
• Diziness
• Low blood pressure
• Fever
• Swelling of your arms, legs, hands, of feet
• Vomiting
• Tiredness 
• Shortness of breath

This medication may cause fertility problems in males, which may affect your ability to become a father. Consult your doctor before taking this medication.

What should I tell my doctor before taking Ventoxen 100 mg tablets?

Tell your doctor if you have

• Any medical conditions, including heart problems, liver problems, previous blood disease, history of bleeding, and any serious infections.
• If you are taking any prescription, non-prescription, vitamins, herbal supplements, or blood thinner medications.
• If you are pregnant or planning to become pregnant. Treatment with Ventoxen 100 mg during pregnancy can affect your fetus in the womb. Or if you are already pregnant, consult your doctor before taking it.
• If you are breastfeeding or planning to breastfeed, active ingredients in the medication may pass through breast milk and enter into child’s body, which may harm the child.

How should I store Ventoxen 100 mg Tablet?

• Store the medicine at room temperature in a dry place, keep it away from direct sunlight, and an overheated area like the kitchen.
• Keep the tablets in the original container.

Frequently Asked Questions about Venetoclax

What if I miss a dose of Ventoxen?

If you miss a dose and you recall it immediately, then take the medicine. If you remember after a long time, do not take the missed dose; inform your doctor. They will suggest to you what you should do. Taking an overdose to recover the missing dose can cause serious side effects. If you vomit after taking a normal dose, and a tablet comes out with your vomit, ask your doctor what you should do.

Can I drink alcohol with venetoclax?

Alcohol is not recommended while taking the medication. Drinking can increase liver strain and may worsen side effects such as nausea, tiredness, or low blood counts—talk to your oncologist about your liver tests and blood counts before drinking even small amounts.

How long does Venetoclax work?

It starts working within the first few weeks, and improvement in blood counts is often seen at this time. Its effect can last for months or even years, depending on the type of cancer, how your body responds, and maintenance treatment.

Does Venetoclax tablet cause hair loss?

Hair loss is not a common side effect, but it can occur. Most patients do not experience significant hair thinning during or after the treatment.

What is the price of Venetoclax 100 mg?

Prices vary by country, brand (branded versus generic), and dose. Generic 100 mg tablets are typically less expensive than the branded product. For a current price, request a quote from a hospital pharmacy or an authorized distributor and check whether your insurance covers the treatment.

How to buy Venetoclax online?

Venetoclax 100 mg (Ventoxen) can be purchased online from licensed pharmacies or authorized medical suppliers. Always verify the pharmacy’s credentials, ensure a valid prescription is required, and confirm product authenticity and shipping regulations before completing the purchase to ensure safe access.

Disclaimer: Information above is not for use as a medical advice alternative; always consult your doctor before taking any prescription medicines.