Osimert 80 mg (Osimertinib) is used to treat metastatic non-small cell lung cancer with EGFR mutation. It is manufactured and marketed by Everest Pharmaceutical in Bangladesh. This medication is available for worldwide delivery.
What is Osimert 80 mg?
Osimert 80 mg is a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor. This targeted therapy is used to treat EGFR exon 19 deletions or exon 21 L858R mutations and T790M mutations in metastatic non-small cell lung cancer.
This lung cancer generic medication is widely accepted by health care specialists and doctors as an effective treatment option. This medication has been tested and inspected by the authorities for quality and safety before being licensed for public use.
How does Osimert 80 mg (Osimertinib) work?
It works by blocking the EGFR mutation in metastatic non-small cell lung cancer.
FDA approval and Indications
The USA Food and Drug Administration has approved Osimert 80 mg (Osimertinib) for the following indications
- As a first line treatment for adult patients to treat tumor in NSCLC with EGFR mutation. In EGFR, it targets specific mutations such as exon 19 deletion or exon 21 L858R.
- As an adjuvant therapy after surgical resection in adult patients with NSCLC and tumor with EGFR exon 19 deletion or exon 21 L858R.
- The FDA has also approved this medication to treat locally advanced or metastatic EGFR T790 mutation-positive NSCLC.
- And further it also can be used for those patients, whose disease has progressed during first line treatment with EGFR TKI.
Dosage and Administration
The recommended dose to treat NSCLC with Osimertinib is 80 mg daily once with or without food.
- Do not crash or chew the tablets.
- If you can not take the tablet whole by mouth, you can disperse one 80 mg tablet in 60 ml non carbonated water. As the tablet turns into small pieces, swallow the suspension. Rinse the pot with 120ml-140ml water and drink it.
- If a nasogastric tube is required to administer the tablet, disperse with 15 ml water and put it in the tube, then add additional 15 ml water to rinse the tube. Do not change your prescription without doctor’s permission.
Side Effects and Precautions of Osimert 80 mg (Osimertinib)
This medication can cause mild to severe side effects depending on patients health condition, medical history or history of other disease.
Common side effects:
- Increased risk of infection: fever, muscle aches, headache, feeling cold, shivering and tired
- Bruising, bleeding gums or nosebleeds
- Diarrhea
- Skin problems include skin rashes, dry skin and itching
- Mouth ulcers
- Anorexia
- Stomach-ache
- Nausea, vomiting
- Back-ache
- Headache
- Pain, discoloration, infection, or other problems with fingernails or toenails.
Rare side effects:
- Hives
- Increased blood creatinine levels
- Thinning hair or complete hair loss
- Inflammation and scarring of lung tissue causing difficulty breathing, coughing or high fever
- Redness and peeling of the hands and feet (called hand-foot syndrome or plantar fasciitis)
- Swelling of the face, lips, tongue, or throat.
Call your doctor right away if you notice the following rare side effects:
- Rash, blistering or peeling of the skin.
- Heart problems such as changes in heart function (QTc prolongation) or heart failure causing shortness of breath, rapid or pounding heartbeat, chest pain, etc.
- Keratitis causes eye pain, watery eyes, sensitivity to light, blurred vision, and red eyes.
- Cutaneous vasculitis causes bruises or skin rashes on the arms, legs, buttocks, or all over the body.
- Nail problems, including swelling around the nail, brittle nails, dryness, pain, discoloration, or ridges. The skin around the nail becomes swollen, red, painful, or infected.
- Swelling of the ankles or feet.
- Feels like I might pass out.
- Persistent fever, bruising or bleeding, pale skin, unusual tiredness or weakness, or any other signs of infection.
- Osimert can cause serious side effects like problems with heart, lungs, and eye vision. If you feel any of that immediately call your doctor and inform them.
- Your doctor may ask you to stop treatment temporarily or permanently or reduce the dose of the medication depending on the side effects you experience.
However the information above only for general purpose always follows your doctor’s prescription before taking osimertinib.
Precaution and Warnings
- Do not take osimertinib if you are allergic to it.
- Do not take this drug with saint john’s wort.
- While taking this drug, regular blood tests are required.
- Beside this check your liver, kidney and heart in a regular interval.
Pregnancy and Lactation
Pregnancy is not safe during this treatment. Follow the instruction in pregnancy & lactation
- Do not conceive baby while taking this medication
- Using proper contraception for both male and female is recommended
- If you are already pregnant and the doctor prescribed you this medication, consult with the doctor.
- Chemical substances in the medication can remain for months. Do not get pregnant immediately after discontinuing the drug.
- Do not breast feed during the treatment. It will harm your children.
- Consult your doctor after discontinuing the medication to start breastfeeding.
Storage Instruction
- Store the medication at room temperature.
- Keep it away from direct sun light.
- Keep it reach out of children.
- Do not store it beside kitchen.
- Do not store it at wet place.
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Osimert 80 mg (Osimertinib) Price
Osimert 80 mg price in Bangladesh is about $100 but the price can be changed any time. To check the latest pricing contact us.
Osimert price in Vietnam
Price of Osimert 80 mg in Vietnam is about 4,576,500 VND.
Osimert Everest
Osimert 80 mg everest means, Everest pharmaceutical is the manufacturer of the drug osimert in Bangladesh. Everest also manufactures others lung cancer drug like Sotoxen, Alecnib and Lorbrexen,Selpercatinib
Frequently Asked Questions (FAQs) about Osimert 80 mg (Osimertinib)
Q: At what temperature should Osimert be stored?
Osimert 80 mg should be stored at below 30 degree C.
Q: How much does Osimertinib cost in Bangladesh?
The cost of Osimert 80mg 30 tablets is about $100.
Q: What is the price of osimert 80 mg in Vietnam?
Osimert 80 mg costs 4,576,500 VND.
Q: Which Therapeutic Class is Osimert 80 mg?
Osimert belongs to cytotoxic chemotherapy.
Q: Where to buy osimert genuine medicine?
You can buy the genuine osimert medicine from Onus Pharma. Which is one of the leading online pharmacy.
Q:What should I do if I miss a dose?
If you miss a dose you should take it immediately after if the time is close to the missed dose. Do not take that dose if the next dose time is closer. Do not take an overdose just go with your next dose as a regular dose. Inform your health care if you miss a dose of osimert.
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