Ibruxen 140mg Capsule Ibrutinib

Ibruxen 140 mg Uses

Ibruxen 140mg Capsule is a treatment option for patients with Mantle Cell Lymphoma(MCL) who have received at least one prior therapy. It is also indicated for Waldenstrom Macroglobulinemia (WM) and Marginal Zone Lymphoma (MZL). Ibruxen inhibit the protein Bruton’s tyrosine kinase (BTK), which liable for cancer cell growth in the blood. By inhibiting this protein Ibruxen helps patients to reduce the intensity of this type of cancer.

What is Ibruxen 140 mg Capsule?

Ibruxen 140 mg capsule is the brand name of Ibrutinib. And each  ibruxen 140 mg capsule contains ibrutinib 140 mg composition. Ibruxen is in a class of Bruton’s tyrosine kinase inhibitor. Which is used to treat a specific type of blood disease called Mantle cell lymphoma. That is a rare type of white blood cell cancer formed in the mantle zone. Ibruxen is applied in those patients who have received at least one prior therapy.

Ibruxen 140 mg capsule is manufactured and distributed by Everest Pharmaceutical Bangladesh. Though it is a generic medicine, It is widely accepted because of its effectiveness in treating this rare blood cancer. Onus Pharma is one of the suppliers of this medication around the world.

Ibruxen 140 mg Indications

Ibruxen 140 mg is indicated to treat several blood disease including Mantle cell lymphoma and the rests are

Chronic lymphocytic leukemia(CLL)/ Small lymphocytic lymphoma(SLL)

Ibruxen 140mg Capsule is indicated to treat CLL/SLL as first line treatment in adult patients. It is also used in patients with or without 17p deletion, a high risk genetic abnormality.

Mantle Cell Lymphoma(MCL)

Mantle cell lymphoma is an aggressive type of B-cell lymphoma. Ibruxen 140 is indicated to use in the patients who have received at least  one prior therapy.

Waldenström’s Macroglobulinemia (WM)

Ibruxen capsule is indicated to treat as first line or subsequent treatment for WM.

Marginal Zone Lymphoma (MZL)

Ibruxen is indicated to treat MZL patients who have received at least one prior anti-CD20-based therapy

Chronic Graft-versus-Host Disease (cGVHD)

It is also indicated as a potential treatment option for (cGVHS)

Ibruxen 140 mg Price

Ibruxen 140 mg price depends on various factors like time, location and dosage.But the general price is $200. The price can be changed at any time depending on the factors. Onus Pharma is giving this medicine at an affordable cost. If your doctor prescribes you Ibruxen 140 mg contact with onus pharma to get the authentic medicine. We have mentioned specific Ibruxen costs for some specific countries.

Ibruxen 140 mg Price in Pakistan

Cost of Ibruxen 140 mg in Pakistan is 60,000 Pakistani rupees for one box. For higher quantities the price will be lower than that. To make your purchase contact with Onus Pharma.

Ibruxen 140 mg Price In Bangladesh

In Bangladesh ibruxen will cost 22,000 BDT in local currency. Price is flexible and can be reduced depending on dosage.

Ibruxen 140 mg price in India

Cost of Ibruxen 140 mg in India is about 17,000 Indian rupees, which is much lower in comparison to other available pharmacies.

Buy Ibruxen Online

There are many online stores you will find but all of them are not trustworthy. That is why people get confused about where to buy these life saving medicines. Onus pharma ensures you 100% authentic medicine with the fastest delivery around the world. If you are looking to buy Ibruxen 140 mg online contact Onus Pharma at +8801540071497 (WhatsApp, Telegram, and direct call) otherwise you can contact us through email: onusbd100@gmail.com. We are also available at WeChat: OnusPharma(WeChat user name). You can search by this name on WeChat to find us from China, South Korea and Vietnam.

Ibruxen Dose

Ibruxen 140mg Capsule is an oral medication, patients have to take this by mouth. Patients always must follow their doctor’s prescription for ibruxen dosage guidelines. The doses are  recommended below for only general purpose. 

Chronic lymphocytic leukemia(CLL)/ Small lymphocytic lymphoma(SLL)

• Dose: 420 mg (3 capsules of 140 mg) once daily.
• Administration: Taken orally at the same time each day, with or without food.

Mantle Cell Lymphoma(MCL)

• Dose: 560 mg (4 capsules of 140 mg) once daily.
• Administration: Taken orally, with or without food.

Waldenström’s Macroglobulinemia (WM)

• Dose: 420 mg (3 capsules of 140 mg) once daily.
• Administration: Same as above.

Marginal Zone Lymphoma

• Dose: 560 mg (4 capsules of 140 mg) once daily.
• Administration: Same as above.

Chronic Graft-versus-Host Disease (cGVHD)

• Dose: 420 mg (3 capsules of 140 mg) once daily.

• Administration: Same as above.

Ibruxen 140 mg Uses

• Capsules must be swallowed whole with water; do not chew, break, or open them.
• Maintain consistent timing daily to avoid missing doses.
• If a dose is missed and it has been less than 12 hours, take the missed dose immediately. If more than 12 hours have passed, skip the missed dose and resume the regular schedule.

Ibruxen 140mg Capsule Dose Modifications for Side Effects:

Ibrutinib doses may need adjustment or temporary discontinuation in the case of severe side effects such as:

1. Bleeding complications.
2. Infections or fever.
3. Low blood counts (neutropenia, thrombocytopenia).
4. Cardiac events like atrial fibrillation.

Dose reductions are typically made as follows:

• First reduction: 280 mg (2 capsules).
• Second reduction: 140 mg (1 capsule).
• If further reduction is required, treatment is usually discontinued.

Special Considerations:

• Avoid grapefruit and Seville oranges, as they may increase the drug’s levels in the blood.
• Adjust doses in patients with kidney or liver impairment under medical guidance.
• Monitor for interactions with other medications, especially those affecting the liver enzyme CYP3A4.

Ibruxen 140mg Capsule Side Effects

Ibruxen can cause mild to moderate side effects depending on the patient’s health condition and medical history. The side effects mentioned below are only for general knowledge. If you notice any of them contact your doctor.

Serious side Effects of Ibruxen 140 mg

Bleeding Problems:

• Serious bleeding (e.g., in the brain or gastrointestinal tract).
• Risk increases if combined with anticoagulants or antiplatelet drugs.

Infections:

• Severe infections, such as pneumonia or sepsis.

Heart Problems:

• Atrial fibrillation or irregular heart rhythm.
• Heart failure or other cardiovascular complications in rare cases.

Hypertension:

• New or worsening high blood pressure.

Second Primary Malignancies:

• Slightly increased risk of developing other cancers, such as non-melanoma skin cancer.

Tumor Lysis Syndrome (TLS):

• A rare but serious condition caused by the rapid breakdown of cancer cells.

Liver Damage:

• Elevated liver enzymes indicating liver stress or damage.

Severe Allergic Reactions:

• Hypersensitivity reactions (rare).

Common side Effects of Ibruxen 140 mg

Gastrointestinal Symptoms:

• Diarrhea (most common).
• Nausea or vomiting.
• Abdominal pain.
• Decreased appetite.

Fatigue:

• Feeling tired or weak.

Blood-Related Issues:

• Low blood counts (anemia, neutropenia, or thrombocytopenia).
• Increased risk of bruising or bleeding.

Musculoskeletal Pain:

• Joint pain or muscle aches.

Infections:

• Increased susceptibility to infections (e.g., bacterial, viral, or fungal).

Rash:

• Mild skin reactions like redness or itching.

Precautions to Minimize Ibruxen 140 mg Side Effects:

• Monitor for bleeding, infections, and blood pressure regularly.
• Stay hydrated and eat small, frequent meals to reduce gastrointestinal symptoms.
• Avoid grapefruit or Seville oranges, which may interact with ibrutinib.

Pregnancy and Lactation precaution for Ibruxen 140mg Capsule

It can cause harmful reaction to fetus if patient take ibruxen during pregnancy or being pregnant during taking ibruxen can cause miscarriage of fetus. So, patient should not take ibruxen during pregnancy.

Though there is no specific information about ibruxen during breast feeding and patients should avoid breast feeding if  they have to take ibruxen.

Storage

Store below 30 degree C temperature and away from children to keep medicine safe and effective.

FAQS about Ibruxen 140mg Capsule

Q: What is the price of Ibruxen in India?

The price of Ibruxen 140mg 120 capsules will be 17,000 Indian rupees. though there are 30 and 60 capsules bottle available.

Q: How to buy Ibruxen 140mg 120 capsules online.

Onus Pharma is an online supplier of Ibruxen. WhatsApp +8801540071497 at this number to make any query or to order any oncology, anti-cancer or anti-viral medicine.

You may take a look at other blood cancer medicine Ventoxen.