Ibruxen 140 mg price | 120 Capsule | Affordable leukemia treatment

Ibruxen 140 mg Price-Affordable leukemia treatment

The price of Ibruxen 140 mg depends on various factors such as time, location, and dosage. But the general price is $200. The price may change at any time depending on these factors. Onus Pharma is giving this medicine at an affordable cost. If your doctor prescribes leukemia medications, contact Onus Pharma to get authentic medicine.

Ibruxen 140 mg Price in Pakistan

Cost of Ibrutinib 140 mg in Pakistan is 60,000 Pakistani rupees for one box. For higher quantities the price will be lower than that. To make your purchase contact with Onus Pharma.

Ibrutinib 140 mg Price In Bangladesh

In Bangladesh, it costs 22,000 BDT. Price is flexible and can be reduced depending on dosage.

The cost of Ibrutinib in India

The cost of this leukemia targeted therapy in India is approximately 17,000 INR, which is lower compared to other pharmacies.

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Ibruxen 140 mg Uses

Ibruxen Capsule is a treatment option for patients with Mantle Cell Lymphoma(MCL) who have received at least one prior therapy. It is also indicated for Waldenstrom Macroglobulinemia (WM) and Marginal Zone Lymphoma (MZL). This drug inhibits the protein Bruton’s tyrosine kinase (BTK), which is responsible for cancer cell growth in the blood. By inhibiting this protein it helps patients to reduce the intensity of this type of cancer.

What is Ibrutinib?

Ibrutinib is a leukemia targeted therapy, approved by the FDA to treat different types of leukemia. Each generic medication contains 140 gm Ibrutinib. This drug is in a class of Bruton’s tyrosine kinase inhibitor. which is used to treat a specific type of blood disease called Mantle Cell Lymphoma (MCL). This is a rare type of white blood cell cancer formed in the mantle zone. This treatment is applied in those patients who have received at least one prior therapy.

Ibruxen 140 mg capsule is manufactured and distributed by Everest Pharmaceutical Bangladesh. Though it is a generic medicine, it is widely accepted due to its effectiveness in treating this rare blood cancer. Onus Pharma is one of the suppliers of this medication around the world.

Ibruxen 140 mg Indications

It is indicated to treat several blood disease including

• Mantle cell lymphoma
• Chronic lymphocytic leukemia(CLL)/ Small lymphocytic lymphoma(SLL) in patients with or without 17p deletion. 17p deletion a high risk genetic abnormality.
• Mantle Cell Lymphoma(MCL) is an aggressive type of B-cell lymphoma. This medication is used to treat MCL patients who have received at least one prior therapy.
• Waldenström’s Macroglobulinemia (WM)
• Marginal Zone Lymphoma (MZL) in patients who have received at least one prior anti-CD20-based therapy
• Chronic Graft-versus-Host Disease (cGVHD)

Side Effects

It can cause mild to moderate side effects depending on the patient’s health condition and medical history. The side effects mentioned below are only for general knowledge. If you notice any of them contact your doctor.

Bleeding Problems:

• Serious bleeding (e.g., in the brain or gastrointestinal tract).
• Risk increases if combined with anticoagulants or antiplatelet drugs.

Infections:

• Severe infections, such as pneumonia or sepsis.

Heart Problems:

• Atrial fibrillation or irregular heart rhythm.
• Heart failure or other cardiovascular complications in rare cases.

Hypertension:

• New or worsening high blood pressure.

Second Primary Malignancies:

• Slightly increased risk of developing other cancers, such as non-melanoma skin cancer.

Tumor Lysis Syndrome (TLS):

• A rare but serious condition caused by the rapid breakdown of cancer cells.

Liver Damage:

• Elevated liver enzymes indicating liver stress or damage.

Severe Allergic Reactions:

• Hypersensitivity reactions (rare).

Gastrointestinal Symptoms:

• Diarrhea (most common).
• Nausea or vomiting.
• Abdominal pain.
• Decreased appetite.

Fatigue:

• Feeling tired or weak.

Blood-Related Issues:

• Low blood counts (anemia, neutropenia, or thrombocytopenia).
• Increased risk of bruising or bleeding.

Musculoskeletal Pain:

• Joint pain or muscle aches.

Infections:

• Increased susceptibility to infections (e.g., bacterial, viral, or fungal).

Rash:

• Mild skin reactions like redness or itching.

Ibruxen 140 mg (Ibrutinib) Dose and Administration

This is an oral medication, patients have to take this by mouth. You must follow your prescription provided by your doctor, below information is only for general idea

Dosage for Chronic lymphocytic leukemia(CLL)/ Small lymphocytic lymphoma(SLL)

• Dose: Patients should take 420 mg (3 capsules of 140 mg) once daily.
• Administration: It is an orally administrative drug, patients must take this medicine by mouth.

Mantle Cell Lymphoma(MCL)  dose

• Dose: Patients should take 560 mg (4 capsules of 140 mg) once daily.
• Administration: It is an orally administrative drug, patients must take this medicine by mouth.

Waldenström’s Macroglobulinemia (WM) dose

• Dose: Patients should take 420 mg (3 capsules of 140 mg) once daily.
• Administration: It is an orally administrative drug, patients must take this medicine by mouth.

Marginal Zone Lymphoma dose

• Dose: Patients should take 560 mg (4 capsules of 140 mg) once daily.
• Administration: It is an orally administrative drug, patients must take this medicine by mouth.

Chronic Graft-versus-Host Disease (cGVHD) dose

• Dose: Patients should take 420 mg (3 capsules of 140 mg) once daily.

• Administration: It is an orally administrative drug, patients must take this medicine by mouth.

Administration

• Swallow the whole tablet with water, do not crush , or chew the capsule.
• Take the medicine at the same time every day according to your prescription.
• Do not take the missing dose if it has been more than 12 hours. Instead inform your doctor or health care provider.

Dose Modifications of Ibrutinb to avoid Side Effects:

Ibrutinib doses may need adjustment or temporary discontinuation in the case of severe side effects such as:

1. Bleeding complications.
2. Infections or fever.
3. Low blood counts (neutropenia, thrombocytopenia).
4. Cardiac events like atrial fibrillation.

Dose reductions are typically made as follows:

• First reduction: 280 mg (2 capsules).
• Second reduction: 140 mg (1 capsule).
• If further reduction is required, treatment is usually discontinued.

Special Considerations:

• Avoid grapefruit and Seville oranges, as they may increase the drug’s levels in the blood.
• Adjust doses in patients with kidney or liver impairment under medical guidance.
• Monitor for interactions with other medications, especially those affecting the liver enzyme CYP3A4.

Precautions you should take:

• Monitor for bleeding, infections, and blood pressure regularly.
• Stay hydrated and eat small, frequent meals to reduce gastrointestinal symptoms.
• Avoid grapefruit or Seville oranges, which may interact with ibrutinib.

Pregnancy and Lactation

It can cause harmful reactions to the fetus if a patient takes this treatment during pregnancy. Taking this drug while pregnant may lead to miscarriage.

Though there is no specific information about breast feeding and patients should avoid breast feeding if  they are taking this medication

Storage

Store below 30°C and keep out of reach of children to maintain the medicine’s safety and effectiveness.

You may take a look at other blood cancer medicine Ventoxen, Avalet 20 mg (Avatrombopag)

Reference: The Food and Drug Administration