Sonib 200 mg (Sorafenib Tosylate)

Sonib 200 mg (Sorafenib Tosylate): Targeted Therapy for Advanced Cancers

Sonib 200 mg is an oral oncology formulation containing Sorafenib Tosylate, a multi-kinase inhibitor. As a leading targeted therapy, it is used in clinical settings to manage advanced liver, kidney, and thyroid malignancies. It works by inhibiting tumor growth and angiogenesis (new blood vessel formation) in cancer cells, helping to control further tumor progression.

Manufactured by Drug International Ltd, Sonib 200 mg is globally accessible through Onus Pharma, a trusted supplier for oncology medication.

Key Therapeutic Indications and Mechanism

What is Sonib 200 mg (Sorafenib Tosylate) used for?

Sonib 200 mg (Sorafenib Tosylate) may be prescribed for patients diagnosed with the following advanced conditions:

• Hepatocellular Carcinoma (HCC): For patients with unresectable HCC who cannot proceed with other treatments.

• Advanced Renal Cell Carcinoma (RCC): For advanced kidney cancer that has spread to other parts of the body.

• Differentiated Thyroid Carcinoma (DTC): For progressive, radioactive iodine-refractory thyroid cancer.

How does Sonib 200 mg tablet work in cancer treatment?

Sonib 200 mg is a multi-kinase inhibitor. It targets both tumor cell proliferation and angiogenesis by blocking intracellular and cell surface kinases (such as CRAF, BRAF, VEGFR, and PDGFR) that are critical for tumor growth and blood vessel formation. This dual mechanism ability is considered beneficial for patients who have not responded to standard therapy for these diseases.

Dosage Instructions and Administration Guide

The typical recommended daily dose of Sorafenib is 400 mg (two 200 mg tablets) taken twice daily.

• Administration: Take Sonib 200 mg with water on an empty stomach (one hour before or two hours after eating).

• Duration: Treatment should continue until clinical benefit is observed or unacceptable adverse effects are noted.

• Missed Dose: Skip the missed dose and continue with the next scheduled dose. Do not double up.

Side Effects and Risk Management (Precautions)

Sonib 200 mg (Sorafenib Tosylate) is associated with serious adverse reactions and requires careful management.

Serious Side Effects

• Cardiac Ischemia and Infarction

• Hemorrhage (Bleeding)

• Hypertension (High Blood Pressure)

• Hand-Foot Skin Reaction (HFSR) and Rash

• Gastrointestinal perforation

Precautions and Risk Mitigation

• Cardiac Ischemia/Infarction: Temporary or permanent discontinuation should be considered if patients develop cardiac ischemia or infarction.

• Risk of Hemorrhage: If bleeding requires medical intervention, permanent discontinuation is advised. Regular checks of prothrombin time and INR are needed if co-administered with Warfarin.

• Risk of Hypertension: Severe or persistent hypertension despite treatment may require temporary or permanent discontinuation.

• Dermatologic Toxicities (HFSR): Management involves dose reduction or interruption based on the severity grade (e.g., Grade 3 requires immediate interruption).

• Wound Healing Problems: Resuming this medication after major surgery should be based on clinical judgment about wound healing.

• Hepatic Impairment: Sonib 200 mg has not been studied in patients having severe liver impairment (Child-Pugh C); hence, caution should be exercised or avoided in this group.

Drug Interactions and Contraindications

Drug Interactions

Discuss with your physician if you are taking any of the following, as they may alter the drug’s effectiveness or safety:

• CYP3A4 Inducers (e.g., rifampin, phenytoin, carbamazepine, St. John’s Wort) may reduce Sorafenib blood levels.

• CYP3A4 Inhibitors (e.g., ketoconazole, clarithromycin) may increase the level of Sorafenib in the blood.

• Warfarin and other anticoagulant drugs increase the risk of bleeding.

• Medications that prolong the QT interval (e.g., amiodarone) might raise the chance of heart rhythm problems.

• Docetaxel & Doxorubicin: May increase the plasma amounts of these drugs.

Contraindications

Sonib 200 mg (Sorafenib Tosylate) is potentially contraindicated in cases of:

• Hypersensitivity to the drug.

• Severe hepatic impairment (Child-Pugh C).

• Pregnancy and breastfeeding.

• Uncontrolled hypertension or severe cardiac conditions.

• Use in combination with carboplatin and paclitaxel in patients with squamous cell lung cancer.

Special Population Use

• Renal Impairment: No dosage adjustment is needed for patients with mild, moderate, or severe renal impairment.

• Geriatric Use: Geriatric effectiveness may not be significantly different, but careful monitoring is advised.

Storage and Price

Storage

Store the medication below 30°C in a dry place, away from sunlight and moisture. Keep it in the original bottle with the desiccant and cap tightly closed.

Sonib tablet price in Pakistan and Bangladesh – Updated 2025

The price of Sonib 200 mg in the region may cost about $90 – $100 USD for a small supply, but the specific unit price in Bangladesh is approximately ৳ 120.00 BDT per tablet (Drug International Ltd.), with a box of 4×7 tablets costing around ৳ 3,360.00. Price information may vary by region; consult a licensed distributor for further details.

Disclaimer: This page is for informational purposes only. Please consult your healthcare provider for professional advice. This is not an advertisement or promotional claim.