Lenvanix 4 mg 30 Capsule | Lenvatinib

Lenvanix 4 mg (30 Capsule) is a targeted therapy used to treat a certain type of metastatic thyroid cancer, advanced renal cell carcinoma with everolimus. It is also used to treat unresectable hepatocellular carcinoma. Lenvanix is in a class of tyrosine kinase inhibitors that work by blocking the abnormal growth of cancer cells or slowing them.

It is indicated to treat

• Locally recurrent or metastatic, progressive, radioactive iodine-refractory differentiated thyroid cancer (DTC) in adult patients.
• In combination with Everolimus to treat advanced renal cell carcinoma (RCC) following one prior anti-angiogenic therapy.
• First-line treatment of unresectable hepatocellular carcinoma (HCC).
• Also, to treat Endometrial Carcinoma in combination with pembrolizumab.

Ingredients of Lenvanix 4 mg

• Lenvatinib 4mg and 10mg

How does Lenvanix work?

• Lenvanix blocks the action of proteins called receptor tyrosine kinases (RTKs), which are involved in the growth of new blood vessels that supply oxygen and nutrients to cells and help them grow.
• These proteins can be present in large amounts in cancer cells. By blocking their action, Lenvanix can slow down the rate at which cancer cells multiply and tumours grow, and help cut off the blood supply that cancer needs.

Dosage – How to use Lenvanix 4 mg?

Differentiated Thyroid Carcinoma (DTC)

• The recommended daily dose of Lenvanix is ​​24 mg (two 10 mg tablets and one 4 mg tablet) once daily. The daily dose will be adjusted as needed according to the dose/toxicity management plan.

Dose adjustment and drug discontinuation for DTC

• Management of adverse reactions may require dose interruption, adjustment, or discontinuation of Levnix therapy.
• Mild to moderate adverse reactions should not usually result in interruption of Levanix unless they are intolerable despite optimal management.
• Severe or intolerable adverse reactions require temporary discontinuation of Lenvanix until improvement of the mild side effect occurs.

Hepatocellular carcinoma

• The daily dose of Lenvanix is ​​8 mg (two 4 mg tablets) once daily for patients weighing <60 kg and 12 mg (three 4 mg tablets) once daily for patients weighing ≥60 kg.
• Dose adjustments are based solely on observed toxicity and not on changes in body weight during treatment. Daily doses will be modified, as necessary, according to the dose/toxicity management plan.

Dose adjustment and drug discontinuation for HCC

• Management of some adverse reactions may require dose interruption, adjustment, or discontinuation of lenvatinib therapy.
• Mild to moderate adverse reactions generally do not require discontinuation of lenvatinib treatment unless they are intolerable to the patient despite optimal management.

How to use Lenvanix

• The medicine can be taken before or after meals.
• Swallow the capsule whole with water or dissolve it. Dissolve by soaking the capsule for 10 minutes, then stirring for 3 minutes until dissolved.
• You can take the medicine with fruit juice, such as apple juice.
• Take Lenvanix at the same time every day.
•  Caregivers should not open the capsule to avoid exposure to the active ingredient inside the capsule.

Pregnancy and lactation

Findings from animal studies indicate that taking Lenvanix during pregnancy may harm the fetus in the womb. The suggestion is not to take this drug while pregnant or to use proper contraception during this treatment. There is no available data on humans that it is harmful or not. But from animal studies, researchers have assumed that it may harm.

Breastfeeding during treatment with Lenvanix is not recommended, because breast milk may contain chemical substances of Lenvanix and harm children.

Lenvanix 4mg side effects

Serious side effects of Lenvanix

• Feeling numb or weak on one side of your body, severe headache, seizures, confusion, Difficulty speaking, vision changes, or feeling dizzy.
• Chest pain or pressure, pain in the arms, back, neck, or jaw, shortness of breath, fast or uneven heartbeat, cough, bluish colour to lips or fingers, feeling very tired.
• Severe pain in the abdomen (belly).
• Black, tarry or bloody stools or coughing up blood – these could be signs of bleeding inside your body.
• Yellow skin or eyes (jaundice) or drowsiness, confusion, poor concentration – these could be signs of liver problems.
• Diarrhea.

Very common side effects of Lenvanix

• High or low blood pressure, loss of appetite or weight loss. Feeling sick and ill, constipation, diarrhoea, stomach pain, and  indigestion
• Feeling very tired or weak, hoarse voice, swelling in the legs. Dry rash, sore or inflamed mouth, strange taste sensation
• Joint or muscle pain, feeling dizzy, hair loss, and trouble sleeping.
• Bleeding (most commonly nosebleeds, but other types of bleeding include blood in the urine, bruising, bleeding from the gums or intestinal wall)
• Changes in urine tests for protein (high) and urinary tract infections (increased frequency of urination and pain when urinating
• Headache and back pain, redness, pain and swelling of the skin in the hands and feet (hand-foot syndrome)
• Underactive thyroid (fatigue, weight gain, constipation, feeling cold, dry skin)
• Changes in blood test results for potassium levels (low) and calcium levels (low)
• Decreased white blood cell count, changes in blood test results for liver function
• Low blood platelet counts can lead to bruising and poor wound healing.

Common side effects of Lenvanix

• Loss of body fluids (dehydration), rapid heartbeat
• Dry, thick and itchy skin.
• Heart problems or blood clots in the lungs (shortness of breath, chest pain) or other organs
• Liver failure, drowsiness, confusion, poor concentration, and loss of consciousness can be signs of liver
  failure
• Feeling unwell, cholecystitis, stroke
• Anal fistula (a small channel that forms between the anus and the surrounding skin)
• Changes in blood test results for magnesium (low), cholesterol (high), and thyroid-stimulating
  hormone (high)
• Changes in blood test results for kidney function and kidney failure
• Increased lipase and amylase (enzymes involved in digestion)

Lenvanix Price

In general, lenvanix 4 mg cost is $170, which is very low in terms of LENVIMA and lenvanix 10 mg cost is $360. The price is variable over time and places. To know the price of Lenvanix in your location, contact us. People also ask about

• Lenvanix 4 mg price in the UAE is 625 dirham.
• Lenvanix 10 mg price in Pakistan is 100,000 rupees.

Storage

Store below 30°C in a dry place away from direct sunlight and children.

FAQs about Lenvanix 4 mg

What is the price of Lenvanix 4 mg for 30 capsules?

The price of Lenvanix 4 mg 30 capsule is $170, and for Lenvanix 10 mg 30 capsule $360.

What should I do if I miss a dose of Lenvanix?

If you miss a dose or take an overdose, do not take a double dose in case of a missed dose and do not miss the next dose because you have taken an overdose. Or immediately consult with your doctor.

See also Lenvaxen, a similar product from Everest Pharmaceuticals.