Adakras (Adagrasib 200 mg tablet)

Adakras (Adagrasib 200 mg tablet) is an inhibitor of the RAS GTPase family, approved by the FDA. 

• It is used as a single therapy to treat KRAS G12C-mutated locally advanced or metastatic NSCLC in adult patients determined by an FDA-approved test who have received at least one prior therapy.
• It is also used in combination with cetuximab for the treatment of adult patients with KRAS G12C-mutated locally advanced or metastatic colorectal cancer that has been determined by an FDA-approved test, and who have received prior treatment with fluoropyrimidine-, oxaliplatin-, and irinotecan-based chemotherapy.

Adagrasib 200 mg Mechanism of Action

Adakras, as an inhibitor of the RAS GTPase family, inhibits the KRAS G12C protein in locally advanced or metastatic non-small cell lung cancer and in colorectal cancer. Inhibiting those proteins, Adakras helps slow down and stop the cancer cells’ growth.

Adagrasib Tablet dosage and administration

• Take 600 mg as a single therapy to treat KRAS G12C-mutated locally advanced or metastatic NSCLC.
• Take 600 mg in combination with cetuximab for the treatment of KRAS G12C-mutated locally advanced or metastatic colorectal cancer.
• Swallow the tablet whole with or without food.
• Take the exact dose instructed on the prescription label.
• For better clarification, consult with your healthcare provider.

Side effects of Aagrasib 200 mg tablet

These common side effects were experienced when it was used as a single therapy to treat NSCLC

• Nausea
• Diarrhea
• Vomiting
• Fatigue
• Musculoskeletal pain
• Hepatotoxicity
• Renal impairment
• Edema
• Dyspnea
• Decreased appetite

Additionally, these side effects were experienced when it was used in combination with cetuximab 

• Headache
• Abdominal pain
• Dry skin
• Anemia
• Cough

Warnings and precautions

Consider the listed warning and take precautions before taking Adakras 200 mg 

• Observe patients for gastrointestinal adverse reactions such as nausea, vomiting, diarrhea, and take necessary steps.
• Monitor patients, especially those who have heart problems. Perform ECG and electrolytes, particularly potassium and magnesium tests, before and during the treatment.
• Healthcare providers should perform liver tests before starting treatment and for 3 months after the treatment as clinically indicated. 
• Monitor patients for Interstitial Lung Disease (ILD) / Pneumonitis and perform required tests before, during the treatment, and after the treatment.
• A health care provider may withhold, reduce the dose, or permanently stop the treatment in case of severe reactions.

Tell your doctor before taking Adakras 200 mg

• If you have any liver problems, lung problems, or heart problems.
• Tell your doctor about the medication you are taking, prescription, non-prescription, vitamins, and herbal supplements.
• If you are pregnant or planning to become pregnant. Ingredients in Adagrasib may harm your unborn baby.
• If you are breastfeeding or planning to breastfeed. Adagrasib may harm your newborn baby.

What should I do while taking Adagrasib 200 mg?

• Use proper contraception to prevent unwanted pregnancy. It is important to use effective contraception for both male and female partners.
• Do pregnancy tests during the treatment.

Storage and Disposal of Adakras

Store Adakras at room temperature, tightly closed in the original container it comes with. Keep it away from children, excessive heat, and moisture. Dispose of the expired or unused medication at a safe place away from children and pets. Do not throw unused medication into the drain or the dustbin.

Price of Adagrasib 200 mg tablet in the UK

The price of generic Adagrasib (Adakras) in the UK is approximately a couple of hundred  GBP, which is not fixed. Price may vary depending on local availability, drug administration approval, and import tax of the medication. Adakras is a globally accessible medication, and Adagrasib has been approved for the treatment of the above indications. Consult with your health care provider before purchasing any prescription medicines online.