Daconib 45 mg Tablet (Dacomatinib)

Daconib (Dacomitinib 45 mg tablet) is an oral small-molecule kinase inhibitor. It was approved by the FDA on September 27, 2018, for the first-line treatment of non-small cell lung cancer in adult patients with epithelial growth factor receptor (EGFR) exon 19 deletion mutation or exon 21 L858R substitution.

What is Daconib 45 mg Tablet used for?

Dacomatinib has been approved for the first-line treatment of adult patients with metastatic non-small cell lung cancer with an FDA-approved test and whose tumors have an EGFR exon 19 deletion or exon 21 L858R substitution mutation. Continue the medication until disease progression or unacceptable toxicity.

How does Daconib 45 mg work?

Daconib 45 mg is an irreversible inhibitor (that permanently blocks the action of an enzyme by forming a strong bond with it) of the human EGFR family (EGFR/HER1, HER2, and HER4) and certain EGFR activating mutations (exon 19 deletion or the exon 21 L858R substitution mutation). By blocking those enzymes, it helps slow down the growth of tumors and leads cancer cells to the death. In clinical trials, it has shown improvement compared to Gefitinib in patients with EGFR-mutant metastatic NSCLC.

What is the dose of Daconib Tablet?

• The recommended dose is 45 mg orally once daily with or without food.
• In certain adverse reactions, the recommended first dose reduction is 30 mg once daily, and the second dose reduction is 15 mg once daily.
•  No dose adjustment is recommended for patients with mild to moderate renal impairment.
• No recommended dose has been established for severe hepatic impairment.

How to take Daconib 45 mg?

• Take a 45 mg Daconib tablet orally once daily with or without food at the same time each day. Take the medication exactly as prescribed by your doctor.
• After vomiting a dose or for a missed dose, do not take an extra dose. Instead, skip that dose and take the next regular dose at the same time.
• Avoid taking certain other medications at the same time, such as proton-pump inhibitors. If you are using H2-receptor antagonists, take this at least 6 hours before and 10 hours after taking H2 antagonists.
• Consistency is important; taking the medication at the same time every day helps maintain a steady drug level.

What are the side effects of Dacomatinib?

• Severe or Fatal interstitial lung disease (ILD) can occur during the treatment. Monitor patients for pulmonary symptoms, and if confirmed, discontinue the treatment.
• Severe diarrhea can occur in patients treated with Daconib; withhold treatment or reduce the dose depending on the severity of diarrhea.
• Allergies and skin rash can occur during treatment. If grade-3 or grade-4 allergies occur, withhold the treatment until recovery, then resume the treatment with the same or reduced dose depending on severity.
• Severe embryo-fetal toxicity can occur during the treatment. It is not recommended to use Daconib in pregnancy and lactation. 

What should I tell my doctor before taking Dacomatinib?

• Tell your doctor before taking Daconib 
• If you have frequent diarrhea.
• If you have a history of breathing or lung problems other than lung cancer.
• If you are pregnant or plan to become pregnant. Daconib can harm your unborn baby.
• If you are breastfeeding or plan to breastfeed. 
• If you are taking any medications, supplements, or herbal medicine.
• Tell your healthcare provider if you have any other medical conditions or major surgery.

How to store Daconib?

Store at controlled room temperature: about 20 °C to 25 °C. Keep the medication in the original container away from moisture, light, and out of reach of children. Do not share with others, even if they have a similar condition.

How much does Dacomatinib cost in Bangladesh?

Daconib 45 mg (generic Dacomatinib) price in Bangladesh depends on brand, manufacturer, and region. Cost may vary due to the duration of the treatment. Discuss with the authorized distributor of Dacomatinib in Bangladesh for exact cost information.

How to buy Dacomatinib online?

Dacomatinib is a prescription-only medicine that is not directly available for online purchase. Request a query to the manufacturer or authorized distributor to get this prescription medicine online.

How long does Daconib stay in your system?

According to the FDA label, the half-life of Daconib 45 mg tablets is 70-100 hours in patients. Practically, this means that the drug and its effects may exist for several days (a week or more) after the last dose. However, “staying in the system” does not equal “effectively active” for the full time; the therapeutic and toxic effects may diminish progressively. Complete elimination may take 2-3 weeks in many patients, but it may vary for individuals.

Is Generic Dacomitinib available in Asia?

Yes, Generic Dacomitinib (Daconib 45 mg) is available in Asia, manufactured by Everest Pharmaceuticals, where it is approved by their drug administration.