Palbonix 125 mg Capsule (Generic Palbociclib)

Palbonix 125 mg is a prescription medication used for the treatment of adult patients with Hormone Receptor (HR)-positive, Human Epidermal Growth Factor Receptor 2 (HER2)-negative locally advanced or metastatic breast cancer.

As a generic version of Palbociclib, Palbonix offers the same clinical efficacy as the branded alternative but at a significantly lower cost. It acts as a CDK4/6 inhibitor, blocking the proteins that allow cancer cells to grow and divide.

What is Palbonix 125 mg?

Palbonix 125 mg is a targeted therapy known as a kinase inhibitor. It works by inhibiting cyclin-dependent kinases 4 and 6 (CDK4/6). These kinases are downstream of signaling pathways that lead to cell proliferation. By blocking them, Palbonix helps slow down or stop the growth of cancer cells.

Key Uses: Palbociclib is primarily indicated for HR-positive, HER2-negative advanced or metastatic breast cancer in combination with:

• An Aromatase Inhibitor: For postmenopausal women as initial endocrine-based therapy.

• Fulvestrant: For patients who have experienced disease progression following prior endocrine therapy.

How to Use Palbonix?

• Route: Oral (Take by mouth).

• Instruction: Swallow the capsule whole with a glass of water. Do NOT chew, crush, or break the tablet.

• Timing: Take the medication at approximately the same time every day to maintain consistent levels in your body.

• Missed Dose: If you miss a dose or vomit after taking the dose, do not take an extra dose. Take your next prescribed dose at the regular time.

Always read the patient instruction leaflet inside the box carefully. If you are unsure about the dosage, consult your oncologist.

Safety Information

1. Precautions & Warnings

Before starting Palbonix 125 mg, inform your doctor if you have:

• Liver or kidney disease.

• Heart problems or a history of stroke.

• Signs of infection (fever, chills).

Critical Warnings:

• Lung Issues: This medicine may cause interstitial lung disease (ILD) or pneumonitis, which can be life-threatening.

• Blood Monitoring: Your doctor should perform blood tests every 3 weeks for the first 3 months, and then monthly, to monitor for low white blood cell counts (Neutropenia) and liver function.

• Lifestyle: Avoid alcohol and smoking, as they can weaken your lungs and immune system.

2. Pregnancy & Breastfeeding

• Pregnancy: Palbonix can harm an unborn baby. Do not use during pregnancy. Use effective contraception during treatment and for at least 3 weeks after the last dose. Male patients with female partners of reproductive potential should also use effective contraception.

• Breastfeeding: Do not breastfeed during treatment and for 3 weeks after the final dose.

3. Side Effects

Like all cancer treatments, Palbonix may cause side effects. Contact your doctor immediately if you experience severe symptoms.

Common Side Effects:

• Decreased White Blood Cells (Neutropenia, Leukopenia)

• Fatigue and Weakness

• Nausea and Vomiting

• Mouth sores (Stomatitis)

• Hair thinning or hair loss (Alopecia)

• Diarrhea

• Rash or Dry Skin

Serious Side Effects:

• Hypertension (High blood pressure)

• Signs of blood clots (Thrombotic events)

• Severe lung inflammation (Pneumonitis)

Drug Interactions

Certain medications can affect how Palbonix works or increase the risk of side effects. Avoid consuming Grapefruit or Grapefruit juice, as it increases the concentration of the drug in your blood.

Notify your doctor if you are taking:

• Antibiotics: (Clarithromycin)

• Antifungals: (Itraconazole, Ketoconazole)

• Antivirals: (Ritonavir)

• Other Cancer Meds: Abemaciclib, Axitinib, Crizotinib, etc.

• Vaccines: Avoid live vaccines (Measles, Mumps, Yellow Fever) during treatment.

Frequently Asked Questions (FAQs)

Q: Is Palbonix 125 mg a generic drug?

A: Yes, Palbonix is a generic version of Palbociclib, manufactured by Beacon Pharmaceuticals. It provides a cost-effective alternative to the branded medication while maintaining the same therapeutic standards.

Q: Can I buy Palbonix 125 mg in the USA?

A: Yes, you can order Palbonix online through Onus Pharma. We provide fast shipping to the USA, UK, and other global destinations.

Q: What dietary restrictions should I follow?

A: There is no specific diet, but you must strictly avoid grapefruit and grapefruit products. Ensure you eat a balanced diet to keep your immune system strong.

Q: What should I do if I overdose?

A: Seek emergency medical attention immediately. Do not double your dose to make up for a missed one.