Talaparib 1 mg Tablet (Generic Talazoparib)

What is Talaparib 1 mg (Talazoparib) used for?

Talaparib (Talazoparib) is used for the treatment of (gBRCA) mutated HER2-negative locally advanced or metastatic breast cancer and certain prostate cancer in combination with other medications. It may also be used for other diseases, as suggested by your doctor.

How does Talaparib work (Mechanism of Action)?

Talaparib is a poly (ADP-ribose) polymerase (PARP) inhibitor, works by blocking a protein in cancer cells that helps cancer cells repair damaged DNA and prevents cancer cells from dying. When PARP inhibitors block this protein, cancer cells die, and the tumor shrinks, which helps spread of the tumor to other parts of the body.

Dosage and Administration Guidelines

For Breast Cancer Patients

Patients diagnosed with (gBRCA) who have HER2-negative breast cancer should take 1 mg tablet daily with or without food according to the prescription until disease progression or unacceptable toxicity.

For Prostate Cancer Patients

Patients diagnosed with metastatic castration resistant prostate cancer should take 0.5 mg in combination with Enzalutamide every day with or without food until disease progression or unacceptable toxicity.

What are the common side effects?

The most common side effects of Talaparib (Talazoparib) are listed below. If any of these happen, tell your doctor instantly. 

• High blood sugar
• Blood cell disorder
• Tiredness 
• Changes in liver function test
• Low calcium level or hypocalcemia
• Nausea 
• Vomiting
• Hari loss
• Headache 
• Loss of appetite

These are the common side effects experienced by patients and are listed to raise awareness. If you experience any other side effects, tell your healthcare provider about dosage adjustment or other initiatives. 

Who should not use Talaparib 1 mg (Talazoparib) medication?

Patients who have severe allergic reactions to this medication or any of the ingredients in it should not use this medication.

What should I know about Talaparib (Talazoparib) before using it?

• You can not share the medicine with others if they also have the same conditions unless they are prescribed. 
• Do not use this medication without a prescription.
• Keep it out of the reach of children.
• You have to swallow the whole tablet; you can not crush it, chew it, or drink it with a glass of water.
• Your healthcare provider may also prescribe other medicines to reduce the side effects of it. Continue those medications together according to the prescription.
• You need to do a regular blood monitoring test with your healthcare provider appointment. Do not miss it if you miss you may have blood clots and you do not know about that.
• Use proper contraception during the treatment to prevent an unwanted pregnancy that may harm an unborn baby.

What should I tell my health care provider before starting this medication?

• Tell your healthcare provider about all the medications you are taking, including prescription, non-prescription, and herbal medicines. 
• Consult your current and past health conditions. 
• Tell your doctor if you are pregnant or planning to get pregnant. Your doctor may not suggest this medicine if you are already pregnant, it may harm the unborn baby. If you are already pregnant, your doctor may tell you to wait until you give birth.
• Do not breastfeed if you are taking this medication or if you are already breastfeeding, do not take this medication. Chemical substances in this medication may harm your baby. 
• Infertility may happen if it is used in male patients; talk to your healthcare provider about that.

Does Talaparib (Talazoparib) interact with any foods or other medicines?

No known food interacts with Talaparib 1 mg (Talazoparib), but there are some medicines that may interact with the medication. This list is not a complete list of drugs that interact with Talaparib. Ask your healthcare provider for a more specific list.

• Intraconazole
• Amiodarone 
• Carvedilol 
• Clarithromycin 
• Verapamil 

What should I do if I take an overdose or miss a dose of Talaparib (Talazoparib) 1 mg?

If you take an overdose, incidentally inform your health care provider, they may take steps to reduce the poison of the overdose. And if you miss a dose, take it as soon as possible, and skip the missed dose if it is close to the next dose.

What is the Price of Generic Talaparib in Bangladesh?

The generic brand of Talaparib (1 mg capsule) in Bangladesh, such as Talaparib manufactured by Everest Pharmaceuticals, has a unit price of approximately ৳ 1,400.00 (Bangladeshi Taka).

The total treatment cost will depend on the duration and the number of capsules required for the prescribed dosage.